How would breast cancer be detected in a man?
Men with breast cancer usually have lumps that can be felt.
As men’s breasts are usually not as big as women’s and a mass is therefore more easily palpated by the man. On the other hand, in contrast to women, health care seeking behaviour in men is not well developed and most cases that we see are fairly advanced.
The following tests and procedures may be used:
- Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. The following are different types of biopsies:
- Estrogen and progesterone receptor test: A test to measure the amount of estrogen and progesterone (hormones) receptors in cancer tissue. If cancer is found in the breast, tissue from the tumor is checked in the laboratory to find out whether estrogen and progesterone could affect the way cancer grows. The test results show whether hormone therapy may stop the cancer from growing.
- HER2 test: A test to measure the amount of HER2 in cancer tissue. HER2 is a growth factor protein that sends growth signals to cells. When cancer forms, the cells may make too much of the protein, causing more cancer cells to grow. If cancer is found in the breast, tissue from the tumor is checked in the laboratory to find out if there is too much HER2 in the cells. The test results show whether monoclonal antibody therapy may stop the cancer from growing.
What is the normal treatment?:
Treatments for breast cancer in men and women are generally the same. Many men benefit from a combination of different treatments. Here’s an overview of the various approaches:
- Surgery. The typical treatment for men is a mastectomy, in which the entire breast is removed. Breast-conserving surgery — in which just the tumor is taken out — isn’t usually possible for an obvious reason. Men don’t have much breast tissue to begin with. The surgeon will also take out one or more of the lymph nodes to see if the cancer has spread.
- Radiation Therapy. Radiation is used commonly after surgery fro breast cancer in men, as these tumors are often advanced and without radiotherapy, there is a high chance of recurrence. Chemotherapy. This is treatment with drugs — either taken by mouth or by injection — that attack cancer cells. Chemotherapy is often used after surgery to lower the risk of the cancer coming back. For men with advanced cancer or cancer that has spread to other parts of the body (metastatic cancer), chemotherapy may be the primary treatment.
- Hormonal Therapy. Some kinds of breast cancer need certain hormones to grow. Hormonal therapy blocks the effects of these hormones, choking the cancer. Your doctor might use tamoxifen or other drugs. The effects of the new aromatase inhibitors like Arimidex and Femara — as well as the drug Aromasin, known as an aromatase inactivator — haven’t been studied much in men. Sometimes, removal of the testes is used to reduce the amount of certain male hormones in the system. Men with breast cancer should never take testosterone.
Hormonal therapy is often used after surgery to lower the risk of the cancer coming back. For men with locally advanced or metastatic cancer, it may be the primary treatment.
- Biological Therapy. This is a new approach. Some men have an excess of a protein that makes cancer spread quickly. Herceptin is a drug that’s been approved to treat metastatic breast cancer. It stops this protein from making the cancer cells grow. It may also boost your immune system, giving it more strength to fight the cancer itself.
What role do male hormones and/or estrogen play?
Evidently hormones play an important role, but because the incidence of the disease in men is so rare, there is not intensive research available and the precise role of hormones is unknown.
Men that are treated with estrogen blockers – does this have an effect? E.g. mood swings, feeling irritated or angry.
Men have very limited side effects to estrogen blockers. If a man is diagnosed with breast cancer, does this increase the chances of his daughters developing cancer?
Yes. Each man that is diagnosed with breast cancer should go for genetic testing. The chances are high that he is a carrier of the breast cancer gene mutations and therefore this would be inherited by his children.
Are the chances of survival higher for men?
No – the chances for survival are lower than for women for a variety of reasons. The most important being that men are less likely to go to a doctor and therefore present themselves with advanced cancers. Due to the anatomy of the male torso with very little breast tissue, small tumours infiltrate into surrounding tissue which can then easily spread.